Has anyone done VMware + ActiveCluster + WSFC?

Should have some fantastic news about that in the next few weeks at least! Purity is ready for it, waiting for VMware to ship 8.0 U3, and it'll be go time for ac-vvols.

Also not sure if it makes more sense to have separate VMware clusters in each location and attach the pRDM volumes to both clusters or have a single VMware cluster and a bunch of DRS rules.

More and more customers are using stretched clusters

So that is generally what we recommend for ActiveCluster

So just make DRS rules to keep each WSFC VM on hosts in different data centers?

There are a couple ways to do it, but with sitea/siteb type of thing, doing the anti-affinity rules with vm-groups and host groups works well. At the esxi cluster level: 1. create a vm-group-1 with node-1 vms 2. create a vm-group-2 with node-2 vms 3. create a host-group-1 with hosts at site1 4. create a host-group-2 with hosts at site2 5. create rule for vm-group-1 to run on host-group-1 6. create rule for vm-group-2 to run on host-group-2 This works well for uniform configs but is super important with non-uniform configs. If you don't care about the site1/site2 split, then you can just do the vm-rule where vm-1,vm-2 can't run on the same hosts, but it's less effective in making sure that the vms are balanced across sites.